Wellcome Institutional Strategic Support Fund Awards
Dr Andrea Cortese (UCL Institute of Neurology): Identification of novel genetic causes of sensory neuropathy (a common group of peripheral nervous system diseases).
Dr Mehmet Fisek (UCL Division of Medicine): Dendritic integration and sensory processing across extended neural networks in rodent visual cortical areas.
Dr Joseph Hayes (UCL Division of Biosciences): Personalising the pharmacological treatment of bipolar disorder.
Dr Shema Tariq (Institute for Global Health): The PRIME Study (Positive Transitions Through the Menopause): the impact of the menopause transition on the health and well-being of women living with HIV.
Establishing new research groups/ programmes
Dr Aida Andres Moran (UCL Division of Biosciences): Genetic local adaptations and their influence in human phenotypes to understand health disparities across human populations.
Dr Lisa Cabrita (UCL Division of Biosciences): Developing molecular mechanisms of protein misfolding during biosynthesis on the ribosome.
Dr David Redding (UCL Division of Biosciences): Implementing Planetary Health: Using system dynamic models to understand the impact of environmental change on zoonotic health burden in Africa.
Dr Maria Secrier (UCL Division of Biosciences): Genetic aberrations and immune activity patterns underlying metastatic formation in solid cancers.
Dr Seirian Sumner (UCL Division of Biosciences): The role of behavioural plasticity on population viability in changing environments.
Professor Chris Thompson (UCL Division of Biosciences): Understanding how gene expression heterogeneity results in robust cell fate choice during embryonic development.
Laura Cream (UCL Public Engagement) and Simon Denegri (NIHR National Director for Patients and the Public in Research, and Chair, INVOLVE): Developing an integrated and innovative approach to public involvement and engagement to help maximise SLMS Research Impact.
Professor Nicholas Greene (UCL GOS Institute of Child Health) and Dr Filipe Cabriero (UCL Structural & Molecular Biology): Exploring the concept that nutrient-gene and nutrient-microbiome-host interactions in genetically tractable E. coli and E. coli/C. elegans model systems can inform analysis of conserved equivalent metabolic pathways in mammalian disease models.
Dr Jane Kinghorn (UCL Office of the Vice-Provost (Health)): Continued development of UCL’s Drug Discovery Group (DDG) to progress UCLs novel targets and biology and UCL’s Therapeutic Innovation Network (TIN) to establish sister TINs to the cell, gene & regenerative medicine TIN in biologicals and small-molecule drug discovery.
Dr Samuel Solomon (UCL Division of Psychology & Language Sciences) and Dr Jack Wells (UCL Division of Medicine): Functional magnetic resonance imaging (fMRI) of visual pathways in the mouse brain to develop a model system for generic brain systems including neurodevelopmental plasticity and neurodegeneration.
Dr Arantza Barrios (UCL Research Department of Cell & Developmental Biology): Understanding the mechanisms of neural circuit and behavioural plasticity through high-resolution in vivo 4D imaging and neuronal activity in freely moving animals.
Professor Gillian Bates (UCL Institute of Neurology): Establishing a Huntingdon’s Disease Research Centre, within the Sobell Department of Motor Neuroscience and Movement Disorders, for research into neurodegenerative disease.
Professor Robin Ketteler (Medical Research Council Laboratory for Molecular Cell Biology (MRC LMCB) at UCL): Broadening the ‘bioinformatics hub’ to enhance image and data analysis capabilities in cell biology research across UCL.
Dr David Lyons (UCL Wolfson Institute for Biomedical Research, UCL Division of Medicine): Using zebrafish to understand the neuron-glial interactions in neural circuit function
Dr Ivan Pavlov (UCL Institute of Neurology): Understanding epilepsy and the regulation of network behaviour in the brain that is also relevant to neurodegenerative disease and mental health research.
Professor Daniel Raleigh (UCL Institute of Structural and Molecular Biology, UCL Division of Biosciences): Interdisciplinary translational research into amyloid diseases and protein biophysics to understand different diseases, including Alzheimer’s, Parkinson’s, Huntingdon’s and Type 2 diabetes.
Dr Jonathan Rohrer (UCL Institute of Neurology): Development of neuroimaging analysis capability to support the improvement and validation of biomarkers required to evaluate treatment.
Professor Trevor Smart (Neuroscience, Physiology and Pharmacology, UCL Division of Biosciences): Support for multidisciplinary translational research collaborations in neuroscience between UCL and the University of Zurich.
Underpinning technology platforms/ Informatics
Dr Richard Dobson (UCL Institute of Health Informatics, Farr Institute): Development and deployment of an informatics platform that will open up diverse electronic health records for research and audit, leading towards decision support and trials in routine practice.
Professor Henry Houlden (UCL Institute of Neurology): Development of Next Generation Sequencing (NGS) informatics and long term storage of genome data to support the diagnosis of rare diseases.
Professor Henry Houlden (UCL Institute of Neurology): Support for the development of genome sequencing as part of the Neurology Genomics England Clinical Interpretation Partnership (Neuro-GeCIP) for the analysis of rare disease genomes to inform research and diagnostics.
Professor Nicholas Luscombe (UCL Division of Biosciences): Cross-faculty collaborative project for the application of advanced computational approaches for data analytics of electronic health records
Professor Richard Mott (UCL Division of Biosciences): Analysis of the joint impacts of epigenetics and structural variation on complex traits in a range of organisms.
Dr Richard Pearson (UCL Division of Biosciences): Support for strategic partnerships in computational biology research and investment into the Centre for Biodiversity and Environmental Research which specialises in computational intensive research relevant to human health.
Underpinning technology platforms/ Imaging
Dr Gareth Barnes (UCL Institute of Neurology): Investment in a magnetoencephalography (MEG) system, a non-invasive brain imaging methodology, to inform neurobiological research and clinical applications for pre-surgical planning.
Dr Adrian Issacs (UCL Institute of Neurology): Contribution towards a state-of-the-art multi-user longitudinal imaging system to expedite the development of new therapeutic targets through phenotypic screening.